8/3/2023 0 Comments Spike protein in blood![]() Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. Published by Elsevier B.V.Īckermann M., Verleden S.E., Kuehnel M., Haverich A., Welte T., Laenger F., et al. ![]() Furthermore, exogenous heparin/HS can significantly reduce coagulation caused by S protein, pointing to a potential new direction to elucidate the etiology of the virus and provide fundamental support for anticoagulant therapy especially for the COVID-19 critically ill patients.Īnticoagulant therapy Coagulation Heparan sulfate SARS-CoV-2 Spike protein.Ĭopyright © 2021. SARS-CoV-2 S protein at a similar concentration (~10 μg/mL) as the viral load in critically ill patients can cause directly blood coagulation and thrombosis in zebrafish model. Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. Electronic address: complication has been an important symptom in critically ill patients with COVID-19. Electronic address: 6 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: 5 Nantong Laboratory of Development and Diseases, School of Life Science, Co-innovation Center of Neuroregeneration, Key Laboratory of Neuroregeneration of Jiangsu, Ministry of Education, Nantong University, Nantong 226019, China. 4 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.3 Glycosciences Laboratory, Faculty of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom.2 Nantong Laboratory of Development and Diseases, School of Life Science, Co-innovation Center of Neuroregeneration, Key Laboratory of Neuroregeneration of Jiangsu, Ministry of Education, Nantong University, Nantong 226019, China.1 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |